A brilliant surgeon, Dr. Génessier, helped by his assistant Louise, kidnaps nice young women. He removes their faces and tries to graft them onto the head on his beloved daughter Christiane, whose face has been entirely spoiled in a car crash. All the experiments fail, and the victims die, but Génessier keeps trying....

After living seven years with the mechanic Aldo, having a daughter with him, the simple woman Irma is informed that her absent husband had just died in Sydney. She becomes upset when Aldo proposes to marry her and she tells him that she is going to leave him. Unable to explain how much he loves her, Aldo takes their daughter Rosina and travels with her, meeting different women in different places, trying to establish a new relationship and fill the emptiness of his sentimental life. He visits his former lover Elvia; he meets and lives with the widow Virginia, who owns a gas station; he lives with the prostitute Andreina. But these relationships never complete the needy Aldo.

Young poetess Rose Elliot buys a book from a local antique dealer, a diary in Latin of an architect, E. Varelli. She learns of the Three Mothers, and believes her apartment building is one of their houses. She pleads her brother Mark, who is studying musicology in Rome, to come, because she is afraid. Mark's friend Sara reads her letter, which he left behind in class, and discovers the school is run by the Mater Lacrimarum, and is killed for this knowledge. The house of Mater Suspiriorum has already been destroyed, and by the time Mark arrives in New York City, he is investigating his sister's murder.

A young American dancer travels to Europe to join a famous ballet school. As she arrives, the camera turns to another young woman, who appears to be fleeing from the school. She returns to her apartment where she is gruesomely murdered by a hideous creature. Meanwhile, the young American is trying to settle in at the ballet school, but hears strange noises and is troubled by bizarre occurrences. She eventually discovers that the school is merely a front for a much more sinister organization.

A happily married London barrister falls in love with the accused poisoner he is defending.